|
KMID : 0391419920020010065
|
|
Korean Journal of Lipidology
1992 Volume.2 No. 1 p.65 ~ p.71
|
|
|
Restriction Fragment Length Polymorphism of Apolipoprotein C-II Gene in Korean Noninsulin Dependent Diabetes Mellitus Patients with Hyperlipidemia
|
|
최성근
김성운/양인명/김진우/김영설/김광원/최영길/팽정령
|
|
|
Abstract
|
|
|
Apolipoprotein C-II plays a major role in lipoprotein metabolism as a cofactor for lipoprotein lipase, the enzyme involved in the hydrolysis of triglyceride-rich lipoproteins. The elevation of both total serum triglycerides and very-low-density
lipoproteins (VLDL) levels are the most common lipoprotein abnormality, being being found in 20 to 60% of the patients with noninsulin dependent diabetes mellitus(NIDDM).
In order to elucidate the possibility that the genetic defect of apolipoprotein C-II gene may contribute to hyperlipidemia found in Korean NIDDM, the Restriction Fragment Length Polymorphism (RFLP) analysis of apolipoprotein C-II gene using
restriction
endonuclease Taq I was investigated. Two type of polymorphic band in size of 3.8 kd(allele 1) and 3.5 kd (allele 2) were noted. The frequency of allele 2 was 0.61 in NIDDM and significantly higher than that of control (0.47). The frequency of
allele 2
was increased in group of NIDDM with hypertriglyceridemia(>200mg/dl), but the frequency was not increased in control group with hypertriglyceridemia.
The results in this study reveals that the genetic variants of apolipoprotein C-II may be a genetic marker for the NIDDMM with hyperlipidemia.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|